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T16333 |
NKY80
|
Adenylyl cyclase type V Inhibitor |
Adenylyl cyclase
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NKY80 regulates the adenylyl cyclase catalytic activity in heart and lung tissues. NKY80 is a non-competitive inhibitor of adenylyl cyclase type V isoform (IC50s: 8.3 µM, 132 µM, and 1.7 mM for type V, III and II, respe... |
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T10066 |
2',5'-Dideoxyadenosine
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|
Adenylyl cyclase
,
Adrenergic Receptor
,
AChR
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2',5'-Dideoxyadenosine is a potent and non-competitive adenylyl cyclase inhibitor via binding the P-site (IC50: 3 μM). |
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T15658 |
KH7
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cAMP
,
AChR
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KH7 is a soluble inhibitor of adenylyl cyclase (sAC)-specific. It has IC50s of 3-10 μM toward both recombinant purified human sACt protein and heterologously expressed sACt in cellular assays. KH7 is also a cAMP inhibito... |
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T16938 |
ST034307
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Adenylyl cyclase
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ST034307 is an effective and selective inhibitor of adenylyl cyclase 1 (IC50: 2.3 μM). |
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T60003 |
AC1-IN-1
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Adenylyl cyclase
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AC1-IN-1 is a selective inhibitor of adenylyl cyclase type 1 (AC1, IC50 = 0.54 µM). |
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T0322 |
Fipexide
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Dopamine Receptor
,
AChR
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Fipexide (Attentil, Vigilor), a psychoactive drug of the piperazine chemical class, was developed in Italy in 1983. It was served as a nootropic drug in France and Italy, mainly for the therapy of senile dementia, but is... |
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T16275 |
NB001
|
HTS 09836 |
Adenylyl cyclase
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NB001 (HTS 09836) is an inhibitor of adenyl cyclase 1 exhibiting effects on neural and non-neural pain. |
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T83169 |
Adenylyl cyclase-IN-1
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Adenylyl cyclase-IN-1 is a potential adenylyl cyclase inhibitor for ocular hypotonia research [1]. |
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T26869 |
BMS-986122
|
BMS 986122 |
Opioid Receptor
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BMS-986122 (BMS 986122) is a positive allosteric modulator of μ-opioid receptors that increases β-arrestin recruitment stimulated by endomorphin 1 in U2OS-OPRM1 human osteosarcoma cells expressing μ-opioid receptors (EC5... |
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T8702 |
SKF-83566
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Dopamine Receptor
,
5-HT Receptor
,
AChR
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SKF-83566 is a blood-brain permeable and orally active antagonist of D1-like dopamine receptor and a weaker competitive 5-HT2 receptor antagonist with Ki of 11 nM |
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T63893 |
Adenylyl cyclase type 2 agonist-1
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Adenylyl cyclase type 2 agonist-1 is a potent agonist of adenylyl cyclase type 2 (AC2) (EC50: 90 nM). It is a potential lead compound in the fight against respiratory diseases. |
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T2172 |
SQ22536
|
9-(tetrahydrofuran-2-yl)-9h-purin-6-amine,SQ 22536 |
AChR
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SQ22536 (9-(tetrahydrofuran-2-yl)-9h-purin-6-amine) , the adenosine analogue 9-(Tetrahydro-2-furyl)adenine, inhibited adenylate cyclase activity of crude membrane preparations from catfish (Ictalurus melas) and rat isola... |
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T11918 |
Lysipressin
|
Lysine vasopressin,[Lys8]-Vasopressin |
Others
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Lysipressin ([Lys8]-Vasopressin), Induces contraction of the rabbit urinary bladder smooth muscle, activate adenylate-cyclase. Lysipressin is Antidiuretic hormone that have been found in pigs and some marsupial families. |
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T15787 |
LRE1
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Adenylyl cyclase
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LRE1 is a specific and allosteric soluble adenylyl cyclase inhibitor. |
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T8959 |
OS-3-106
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Dopamine Receptor
|
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OS-3-106 is a novel arylamide phenylpiperazines, as partial agonists at the D3R in the adenylyl cyclase inhibition assay. |
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T7813 |
α-MSH
|
MSH, amide,CZEN-002,α-Melanocyte-Stimulating Hormone (MSH), amide |
Melanocortin Receptor
,
Adenylyl cyclase
|
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α-MSH (MSH, amide) is amide stimulates melanocortin 1 receptor that results in the activation of adenylyl cyclase. |
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T64355 |
TDI-10229
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cAMP
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TDI-10229 is a potent and orally available inhibitor of soluble adenylyl cyclase (sAC, ADCY10). TDI-10229 displays nanomolar inhibition of sAC in both biochemical and cellular assays (IC50= 195 nM). TDI-10229 exhibits mo... |
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T22615 |
BPIPP
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Others
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guanylyl cyclase (GC) and adenylyl cyclase (AC) inhibitor |
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T23863 |
CB-6673567
|
CB 6673567 |
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CB-6673567 is a selective inhibitor of adenylyl cyclase. |
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T26960 |
CB7833407
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CB7833407 is a selective Adenylyl Cyclase isoform-2 (AC2) inhibitor. |
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T28622 |
RU-0207148
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RU-0207148 is a novel allosteric soluble adenylyl cyclase (sAC) inhibitor. |
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T22467 |
1,9-Dideoxyforskolin
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Others
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The compound is an inactive analog of forskolin(an adenylyl cyclase activator). |
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T69543 |
CFM-1571(free base)
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CFM 1571 is the free base of CFM 1571 Hydrochloride (C291720), which acts as a soluble guanylyl cyclase (sGC) activator while ignoring adenylyl cyclase. |
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T38782 |
Mant-GTPγS
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Mant-GTPγS, an effective GTP analog, displays strong competitive inhibition of adenylyl cyclase (AC). Additionally, it acts as a potent inhibitor of YdeH. |
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T83843 |
2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate sodium
|
2'(3')-ANT-GTP |
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2'(3')-O-Anthraniloylguanosine-5'-O-triphosphate (2'-ANT-GTP) and 3'-ANT-GTP are fluorescent derivatives of GTP that exhibit spontaneous isomerization. 2'(3')-ANT-GTP features an emission peak at 428 nm when excited at 3... |
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T76657L |
Human PTH-(1-31) amide
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Human PTH-(1-31) amide, an analog of PTH, effectively stimulates phosphatidylcholine hydrolysis and promotes the release of adenylyl cyclase [1]. |
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TP2033 |
[Des-His1,Glu9]-Glucagon amide
|
des-His1-[Glu9]-Glucagon (1-29) amide |
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Glucagon receptor antagonist (pA2 = 7.2 for inhibition of glucagon-induced adenylyl cyclase activation in rat liver membranes); displays no agonist activity. Enhances glucose-stimulated pancreatic insulin release in vitr... |
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T71122 |
Carsatrin (free base)
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Carsatrin is purinylpiperazine derivative. as cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action potential (AP) duration of ventricular muscle... |
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T73297 |
TDI-11861
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|
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TDI-11861, a second-generation soluble Adenylyl Cyclase (sAC, ADCY10) inhibitor, demonstrates slow dissociation rates and effectively inhibits sAC activity in cells, evidenced by an IC50 value of 5.5 nM. |
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T37131 |
MS 15203
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Potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). Exhibits minimal binding to a panel of ~70 GPCRs and 10 other re... |
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T70975 |
Carsatrin succinate
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Carsatrin succinate is the salt form of Carsatin, a purinylpiperazine derivative used as a cardiotonic and antiarrhythmic. Carsatrin acts as positive inotropic agent that increases twitch tension and prolongs the action ... |
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T36720 |
Deacetylforskolin
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Deacetylforskolin is a diterpene and a derivative of forskolin that has been found inC. forskohliiand has diverse biological activities.1,2,3,4It activates rat adipocyte adenylyl cyclase (IC50= 20 μM) and inhibits glucos... |
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T83820 |
TNP-GTP sodium
|
TNP-Guanosine 5'-triphosphate |
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TNP-GTP, a fluorescent derivative of guanosine 5'-triphosphate (GTP), essential for protein synthesis and gluconeogenesis, exhibits an emission peak at 552 nm when excited at 410 nm in water. Its fluorescence intensity i... |
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T83811 |
2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate sodium
|
2'(3')-ANT-ATP |
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2'(3')-O-Anthraniloyladenosine-5'-O-triphosphate (2'-ANT-ATP) and its isomer 3'-ANT-ATP are fluorescent derivatives of ATP that spontaneously isomerize. Emitting a maximum light of 428 nm when excited at 330 nm in water,... |
